Chito-oligosaccharides application

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Chito-oligosaccharides-based material in cosmetic applications

Beauty eco-innovation: discover the wide range of applications of Chito-oligosaccharides in cosmetic formulations

Chitosan Oligosaccharides Introduction

Chitin, which is widely found in shrimp and crab shells, is a polysaccharide made by the polymerization of N acetyl glucosamine.

Chitin is deacetylated to obtain chitosan.

In the past ten years, the research on chitin and chitosan has been widely carried out at home and abroad, and their functions in anti-tumor and prevention and treatment of pathogenic microorganisms have attracted more and more attention. However, due to its insoluble water, it is very limited in the development of applications. To this end, chitosan is degraded into Chito-oligosaccharides (also known as oligosaccharides, chitosan oligosaccharides, chitosan oligosaccharides) by appropriate methods, that is, oligosaccharides composed of 2~10 aminoglycoses linked by β-1-4 glycosidic bonds.

Through a series of experiments, it has been found that it not only has good water solubility, is easy to be absorbed by the human body, but also has a variety of physiological functions such as antibacterial, anti-tumor, blood lipid regulation, immune regulation and activation of intestinal bifidobacteria, and the application field has been greatly broadened.

Chito-oligosaccharides has a unique application value in fine chemicals, biomedicine, health food, agriculture, forestry and animal husbandry.


Chito-oligosaccharides chemical structure

Chito-oligosaccharides is a multifunctional biopolymer derived from chitin that has been widely used in several industries due to its unique properties. This biodegradable and non-toxic compound offers a range of advantages in various areas:

  • Healthcare & Pharmaceutical: The biocompatibility of Chito-oligosaccharides makes it invaluable in medical applications. It is used in wound healing products, drug delivery systems, and as a biomaterial in tissue engineering. Its ability to promote healing and control drug release makes it a popular choice in the pharmaceutical industry.
  • Environmental protection: In water treatment, Chito-oligosaccharides' ability to bind to heavy metals and other contaminants makes it an effective agent in the purification process. This property allows it to be used in industrial and municipal water treatment facilities.
  • Agriculture: Farmers and agronomists utilize Chito-oligosaccharides as natural biostimulants and inducers. It promotes plant growth and strengthens resistance to pathogens, contributing to more sustainable agricultural practices.
  • Food industry: Chito-oligosaccharides have a variety of usages in food production and preservation. It acts as an antimicrobial food additive and can be used to make edible films or coatings to extend the shelf life of perishable products.
  • Beverage production: In the alcoholic beverage industry, Chito-oligosaccharides are used to clarify wine, beer, and whiskey, helping to improve their transparency and stability.
  • Dietary supplements: This compound is also used in the production of dietary supplements, taking advantage of its potential health benefits.
  • Plastics industry: The biodegradable properties of Chito-oligosaccharides make it an attractive option for developing environmentally friendly plastic alternatives.

  • Biological activity. Chito-oligosaccharides has a water solubility of more than 99% and a human absorption rate of 99.88%, which has superior biological activity than chitosan. It can improve the flora distribution of intestinal microbes, stimulate the growth of beneficial bacteria, and its pharmacological activity is 14 times that of chitosan of the same weight. Experiments have shown that Chito-oligosaccharides can proliferate Bifidobacterium by 120 times when applied to dairy products.
  • Antibacterial and antibacterial effect. Chito-oligosaccharides has a pronounced antibacterial and antibacterial effect. Its antibacterial effect is also gradually enhanced with the decrease of the molecular weight of Chito-oligosaccharides, with a molecular weight of 1 814, the degree of deacetylation of 84% Chito-oligosaccharides treated non-woven fabrics, it was found that the concentration of 0.01% against Proteus vulgaris reached 90%, while for Staphylococcus aureus and Escherichia coli, 0.05%, the molecular weight is 2 000~ 30 000, and the degree of deacetylation is 91.5% Chito-oligosaccharides inactivates two oral pathogens, Actinobacillus actinobacillus and Streptococcus mutans.
  • Antitumor effect. Chito-oligosaccharides can improve the body's immune activity and anti-cancer ability, and has a significant inhibitory effect on liver cancer cells.
  • Disease prevention and disease resistance of plants. Chito-oligosaccharides also acts as a plant regulator to enhance the plant's defenses against pests and diseases. Oligosaccharides have the functions of regulating plant growth, development, reproduction, disease prevention and resistance, etc., can stimulate the immune system response of plants, activate defense responses, produce active substances with disease resistance, and inhibit the formation of diseases.
3. What are the benefits of Chito-oligosaccharides in cosmetic applications?

In the ever-evolving world of cosmetic science, the quest for natural active ingredients is timeless. Among them, Chito-oligosaccharides become an extraordinary sustainable option that provides various benefits for skincare and beauty products. We are looking at the properties of Chito-oligosaccharides, its advantages in cosmetic formulations, and its impact on the industry and consumers. Chito-oligosaccharides are known for their biocompatibility, biodegradability, and non-toxicity, making them a beneficial ingredient in cosmetics.

The main advantages of Chito-oligosaccharides for cosmetics:
  • 1. Moisturizes and strengthens the skin barrier: Chito-oligosaccharides are an excellent natural moisturizer. Its hygroscopic nature allows it to retain moisture, which in turn maintains the skin's hydration levels. In addition, it forms a breathable film on the skin that strengthens its barrier function and protects it from environmental stressors.
  • 2. Anti-Aging Properties: Its ability to promote collagen synthesis makes the plant Chito-oligosaccharides a valuable ingredient in anti-aging products. It helps maintain youthful skin by promoting skin elasticity and reducing the appearance of fine lines and wrinkles.
  • 3. Antibacterial and healing properties: The inherent antimicrobial properties of the plant Chito-oligosaccharides make it beneficial for acne treatment and products for infected-prone skin. It also accelerates wound healing, making it suitable for use in post-operative skin care.
  • 4. Enhance product stability and efficacy: In the formulation, the plant Chito-oligosaccharides acts as a natural preservative and stabilizer, extending the shelf life of the product. It is able to form a stable emulsion that enhances the texture and application of cosmetics.
  • 5. Sustainability and eco-friendliness: Chito-oligosaccharides are plant-based and a renewable resource. Its use reflects a commitment to sustainable practices in the cosmetics industry to meet the growing demand for eco-friendly products.
  • Market impact and consumer perception: The inclusion of Chito-oligosaccharides in cosmetics is a strategic move that aligns with the values of environmentally conscious consumers. Its versatile properties not only enhance product performance, but also resonate with the spirit of sustainable and natural beauty solutions. By adopting Chito-oligosaccharides, companies can improve brand reputation, differentiate their products, and tap into the growing natural beauty market.

4. What is the optimal concentration of high-deacetylated, ultra-low molecular weight Chito-oligosaccharides for cosmetic formulations?

The dosage of Chito-oligosaccharides in cosmetics varies depending on the type of product and the desired effect. Typically, Chito-oligosaccharides is used in cosmetic formulations in concentrations ranging from 0.1% to 2%. Here are some guidelines:

1

For creams and lotions designed to moisturize or anti-aging, the optimal concentration of Chito-oligosaccharides is usually between 0.5% and 2%. This concentration range applies to:

  • Moisturizing: Chito-oligosaccharides help keep the skin hydrated, leaving it feeling soft and hydrated.
  • Improves skin elasticity: Chito-oligosaccharides improves skin elasticity, making it look younger and radiant.

Specific requirements for Chito-oligosaccharidesIn order to achieve optimal concentrations, the following requirements should be met:

  • Deacetylation: Chito-oligosaccharides should undergo >98% deacetylation to ensure maximum effectiveness.
  • Molecular weight: The molecular weight of Chito-oligosaccharides should be between 2-5 kDa to ensure optimal absorption and efficacy.

By using an optimal concentration of Chito-oligosaccharides and meeting specific requirements, skincare products can effectively provide moisturizing and anti-aging benefits to the skin.

2. Acne treatment and antimicrobial application

Chito-oligosaccharides are active ingredients in skincare products that target acne treatment or require antimicrobial properties. In these applications, Chito-oligosaccharides are typically used at lower concentrations, typically between 0.1% and 1%.

Benefits of Chito-oligosaccharides in Acne Treatment:
  • Reduces bacterial growth: Chito-oligosaccharides has antimicrobial properties that are effective in reducing the growth of acne-causing bacteria, such as P. acnes.
  • Aids in skin healing: Chito-oligosaccharides promote skin healing by reducing inflammation and stimulating the production of collagen and other skin healing factors.

Effectiveness at lower concentrationsEven at lower concentrations of 0.1% to 1%, Chito-oligosaccharides can provide significant benefits in acne treatment and antimicrobial applications. This is due to its unique properties and mechanism of action:

  • Positive Charge: Chito-oligosaccharides have a positive charge, which allows it to interact with negatively charged bacterial cell membranes, disrupting its function and reducing bacterial growth.
  • Film-forming properties: Chito-oligosaccharides form a protective film on the surface of the skin that helps prevent bacteria and other microorganisms from entering.

Combined with other ingredients in acne treatment and antimicrobial applications, Chito-oligosaccharides are often combined with other ingredients to increase their effectiveness. For example:

  • Salicylic Acid: Chito-oligosaccharides can be combined with Salicylic Acid, a common anti-acne ingredient, to enhance its effectiveness in reducing acne lesions and preventing future breakouts.
  • Tea Tree Oil: Chito-oligosaccharides can be combined with tea tree oil, a natural antimicrobial agent, to enhance its efficacy in reducing bacterial growth and promoting skin healing.

3

By using a lower concentration of 0.1% to 1% Chito-oligosaccharides and combining it with other active ingredients, skincare products can provide targeted and effective acne treatment and antimicrobial benefits.

Chito-oligosaccharides concentration in hair care products Chito-oligosaccharides is a versatile ingredient that can be used in hair care products such as shampoos and conditioners to provide various benefits. In these applications, the concentration of Chito-oligosaccharides is typically 0.1% to 1%. Benefits of Chito-oligosaccharides in hair care

  • Improves hair texture: Chito-oligosaccharides help to improve hair texture, making it feel softer, smoother, and more manageable.
  • Provide strength: Chito-oligosaccharides provide strength to the hair, reducing breakage and split ends.
  • Boosts Hydration: Chito-oligosaccharides help keep moisture in your hair, leaving it feeling hydrated and healthy.

Mechanism of action The benefits of Chito-oligosaccharides in hair care can be attributed to its unique properties and mechanism of action:

  • Film-forming properties: Chito-oligosaccharides form a protective film on the hair shaft that helps to lock in moisture and reduce frizz.
  • Positive Charge: The positive charge of Chito-oligosaccharides allows it to interact with the negatively charged hair cuticle, helping to smooth the cuticle and reduce frizz.
  • Moisturizing properties: The moisturizing properties of Chito-oligosaccharides help to moisturize the hair, leaving it feeling soft and bouncy.

Combined with other ingredients in hair care products, Chito-oligosaccharides can be combined with other ingredients to enhance their efficacy. For example:

  • Protein: Chito-oligosaccharides can bind to proteins such as keratin or collagen to help repair and strengthen hair.
  • Moisturizers: Chito-oligosaccharides can be combined with moisturizers such as glycerin or panthenol to help moisturize and nourish the hair.
  • Antioxidants: Chito-oligosaccharides can be combined with antioxidants such as vitamin E or green tea extract to help protect hair from environmental stress and damage.

By using Chito-oligosaccharides at concentrations of 0.1 to 1 percent and combining them with other active ingredients, hair care products can provide a range of benefits, from improving hair texture and strength to enhancing hydration and reducing frizz.

4

Chito-oligosaccharides in color cosmetics Chito-oligosaccharides is a usages of a wide range of ingredients that can be used in a variety of cosmetics, such as foundation and mascara, to enhance their performance. In these applications, Chito-oligosaccharides concentrations are typically between 0.5% and 1.5%. Benefits of Chito-oligosaccharides in cosmetics

  • Stability: Chito-oligosaccharides help stabilize the formulation, ensuring that the product is consistent and effective over time.
  • Adhesion: Chito-oligosaccharides improves the adhesion of cosmetics to the skin, making the application longer-lasting.
  • Moisturizing: Chito-oligosaccharides help keep skin hydrated and leave skin feeling hydrated and healthy.

Mechanism of action The benefits of Chito-oligosaccharides in cosmetics can be attributed to their unique properties and mechanism of action:

  • Film-forming properties: Chito-oligosaccharides form a protective film on the skin's surface, helping to lock in moisture and extend makeup life.
  • Positive Charge: The positive charge of Chito-oligosaccharides allows it to interact with negatively charged skin surfaces, enhancing their adhesive properties.
  • Moisturizing properties: The moisturizing properties of Chito-oligosaccharides help to attract and retain moisture in the environment, keeping the skin hydrated.

Combined with other ingredients in cosmetics, Chito-oligosaccharides can be combined with other ingredients to enhance their efficacy. For example:

  • Emulsifiers: Chito-oligosaccharides can be combined with emulsifiers such as glyceryl stearate or cetearyl alcohol to improve the stability and texture of the formulation.
  • Moisturizers: Chito-oligosaccharides can be combined with moisturizers such as hyaluronic acid or glycerin to enhance hydration and skin hydration.
  • Thickeners: Chito-oligosaccharides can be combined with thickeners such as xanthan gum or carrageenan to improve the viscosity and texture of the formulation.

By using Chito-oligosaccharides at concentrations of 0.5 to 1.5 percent and combining them with other active ingredients, cosmetics can provide a range of benefits, from improved stability and adhesion to enhanced hydration and overall skin health.

5

Chito-oligosaccharides is used as a stabilizer and preservative in cosmetic formulations Chito-oligosaccharides is a versatile ingredient that can be used as a stabilizer or preservative in various cosmetic formulations. Its concentration can vary from 0.1% to 2%, depending on the specific requirements of the product. Benefits of Chito-oligosaccharides as a stabilizer and preservative:

  • Improves stability: Chito-oligosaccharides help stabilize the formulation, ensuring that the product is consistent and effective over time.
  • Preservative properties: Chito-oligosaccharides have antiseptic properties that help prevent microbial growth and extend the shelf life of the product.
  • Natural and safe: Chito-oligosaccharides are a natural, biodegradable, and non-toxic ingredient that is safe to use in cosmetics.

Formulation Considerations The following formulation considerations should be considered when using Chito-oligosaccharides as a stabilizer or preservative:

  • Concentration: The concentration of Chito-oligosaccharides can vary from 0.1% to 2%, depending on the formulation and stability requirements of the product.
  • pH: Chito-oligosaccharides are most effective between pH 4.5 and 6.5.

6

Combined with other ingredients: Chito-oligosaccharides can be combined with other ingredients to enhance their stabilizing and antiseptic properties.

  • Flavors and essential oils: Chito-oligosaccharides are derived from fungi.
  • It has a variety of benefits when used in perfumes and essential oils:

  • Enhanced Stability: Chito-oligosaccharides can help stabilize volatile compounds in perfumes and essential oils, extending shelf life and maintaining fragrance integrity over time.
  • Controlled release: It can be used to create microcapsules that encapsulate fragrance molecules, thereby controlling and prolonging the release of fragrance.
  • Emulsifying properties: In products where the oil phase and water are combined, Chito-oligosaccharides can act as an emulsifier, ensuring that the essential oils are evenly distributed throughout the product without separation.
  • Increased solubility: Some fragrance compounds are not very soluble in water-based products. Chito-oligosaccharides can increase the solubility of these compounds, resulting in a more uniform odor profile.

The dosage of Chito-oligosaccharides in perfumes and essential oils can vary greatly depending on the desired results and the specific formulation of the product. However, in such applications, Chito-oligosaccharides are typically used at relatively low concentrations, typically between 0.1% and 1%. For example, in spice embedding, the amount of Chito-oligosaccharides used will depend on the method of microencapsulation and the desired release profile. For stabilization and solubilization in perfume or essential oil mixtures, the dosage will depend on the volatility of the oil and the type of product formulated.

Optimizing the Dosage of Vegetable Chito-oligosaccharides in Cosmetic FormulationsWhen using vegetable Chito-oligosaccharides in cosmetic formulations, it is crucial to determine the optimal dosage to achieve the desired effect. However, the ideal concentration can vary depending on a number of factors, including:

  • Types of Plant Chito-oligosaccharides: Plant Chito-oligosaccharides of different grades and molecular weights may produce different effects and require dosage adjustment.
  • Compatibility with other ingredients: Interactions between botanical Chito-oligosaccharides and other ingredients in the formulation can affect the stability, texture, and overall performance of the product.
  • Desired product viscosity: The concentration of vegetable Chito-oligosaccharides affects the viscosity of the product, and the viscosity may need to be adjusted to achieve the desired texture and consistency.

Formulation TestingIn order to determine the optimal dosage of botanical Chito-oligosaccharides for a particular product, cosmetics manufacturers often conduct extensive formulation testing. This includes:

  • Evaluation of different concentrations of plant Chito-oligosaccharides: Testing of different concentrations of plant Chito-oligosaccharides to assess their effect on product performance, stability, and texture.
  • Assess compatibility: Evaluate the compatibility of plant Chito-oligosaccharides with other ingredients in the formulation to ensure that the product is stable and effective.
  • Optimize viscosity: Adjust the concentration of plant Chito-oligosaccharides to achieve the desired viscosity and texture of the product.

The importance of customizationGiven the variability in the effects of the plant Chito-oligosaccharides and the complexity of cosmetic formulations, it is essential to tailor the dosage for each specific product. This ensures that the product meets the required requirements for performance, stability and texture. Determining the optimal dosage of Chito-oligosaccharides in a cosmetic formulation requires careful consideration of a variety of factors, including the type of Chito-oligosaccharides, compatibility with other ingredients, and the desired product viscosity. By conducting comprehensive formulation testing and customizing the dosage of each product, cosmetics manufacturers can unlock the full potential of the plant Chito-oligosaccharides to create effective, stable, and attractive products.

5. Summary of the application of Chito-oligosaccharides in cosmetics

Chito-oligosaccharides is a testament to the potential of natural ingredients to revolutionize cosmetic formulations. Its multifaceted benefits, from enhanced skin health to sustainability, make it a valuable addition to cosmetic ingredients. As the industry continues to embrace green science, Chito-oligosaccharides are expected to play an important role in innovative and serious beauty product development.

Chito-oligosaccharides derivatives: natural alternatives to synthetic cosmetic ingredients

Chito-oligosaccharides derivatives are effective in replacing a variety of synthetic ingredients in cosmetics, including:

  • Film formers: Chito-oligosaccharides can replace synthetic film formers such as polyvinylpyrrolidone (PVP) and polyvinyl acetate (PVA) in hair care products.
  • Moisturizers: Chito-oligosaccharides can replace humectants such as hyaluronic acid, glycerin, and sorbitol in skincare products.
  • Moisturizers: Chito-oligosaccharides can replace humectants such as petroleum jelly, mineral oil, and dimethicone in skincare products.
  • Thickeners: Chito-oligosaccharides can replace thickeners in various cosmetics such as carbomer, xanthan gum, and guar gum.
  • Emulsifiers: Chito-oligosaccharides can replace emulsifiers such as sodium lauryl sulfate (SLS) and sodium laureth sulfate (SLES) in skincare products.
  • Antimicrobials: Chito-oligosaccharides can replace antimicrobials such as triclosan and chlorhexidine in various cosmetics.
  • Anti-aging agents: Chito-oligosaccharides can replace anti-aging agents such as retinol and peptides in skincare products.
  • Sunscreens: Chito-oligosaccharides can replace sunscreens such as oxybenzone and avobenzone in sunscreen products.

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