Chito-oligosaccharides application

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Qilu XinhaiFood-grade chito-oligosaccharides

Harnessing the Power of Crab Shells: Revealing the Revolutionary Role of Chito-oligosaccharides in Dietary Food Supplements

Chitosan Oligosaccharides Introduction

Chitin, which is widely found in shrimp and crab shells, is a polysaccharide made by the polymerization of N acetyl glucosamine.

Chitin is deacetylated to obtain chitosan.

In the past ten years, the research on chitin and chitosan has been widely carried out at home and abroad, and their functions in anti-tumor and prevention and treatment of pathogenic microorganisms have attracted more and more attention. However, due to its insoluble water, it is very limited in the development of applications. To this end, chitosan is degraded into Chito-oligosaccharides (also known as oligosaccharides, chitosan oligosaccharides, chitosan oligosaccharides) by appropriate methods, that is, oligosaccharides composed of 2~10 aminoglycoses linked by β-1-4 glycosidic bonds.

Through a series of experiments, it has been found that it not only has good water solubility, is easy to be absorbed by the human body, but also has a variety of physiological functions such as antibacterial, anti-tumor, blood lipid regulation, immune regulation and activation of intestinal bifidobacteria, and the application field has been greatly broadened.

Chito-oligosaccharides has a unique application value in fine chemicals, biomedicine, health food, agriculture, forestry and animal husbandry.


Chito-oligosaccharides chemical structure

Chito-oligosaccharides is a multifunctional biopolymer derived from chitin that has been widely used in several industries due to its unique properties. This biodegradable and non-toxic compound offers a range of advantages in various areas:

  • Healthcare & Pharmaceutical: The biocompatibility of Chito-oligosaccharides makes it invaluable in medical applications. It is used in wound healing products, drug delivery systems, and as a biomaterial in tissue engineering. Its ability to promote healing and control drug release makes it a popular choice in the pharmaceutical industry.
  • Environmental protection: In water treatment, Chito-oligosaccharides' ability to bind to heavy metals and other contaminants makes it an effective agent in the purification process. This property allows it to be used in industrial and municipal water treatment facilities.
  • Agriculture: Farmers and agronomists utilize Chito-oligosaccharides as natural biostimulants and inducers. It promotes plant growth and strengthens resistance to pathogens, contributing to more sustainable agricultural practices.
  • Food industry: Chito-oligosaccharides have a variety of usages in food production and preservation. It acts as an antimicrobial food additive and can be used to make edible films or coatings to extend the shelf life of perishable products.
  • Beverage production: In the alcoholic beverage industry, Chito-oligosaccharides are used to clarify wine, beer, and whiskey, helping to improve their transparency and stability.
  • Dietary supplements: This compound is also used in the production of dietary supplements, taking advantage of its potential health benefits.
  • Plastics industry: The biodegradable properties of Chito-oligosaccharides make it an attractive option for developing environmentally friendly plastic alternatives.

  • Biological activity. Chito-oligosaccharides has a water solubility of more than 99% and a human absorption rate of 99.88%, which has superior biological activity than chitosan. It can improve the flora distribution of intestinal microbes, stimulate the growth of beneficial bacteria, and its pharmacological activity is 14 times that of chitosan of the same weight. Experiments have shown that Chito-oligosaccharides can proliferate Bifidobacterium by 120 times when applied to dairy products.
  • Antibacterial and antibacterial effect. Chito-oligosaccharides has a pronounced antibacterial and antibacterial effect. Its antibacterial effect is also gradually enhanced with the decrease of the molecular weight of Chito-oligosaccharides, with a molecular weight of 1 814, the degree of deacetylation of 84% Chito-oligosaccharides treated non-woven fabrics, it was found that the concentration of 0.01% against Proteus vulgaris reached 90%, while for Staphylococcus aureus and Escherichia coli, 0.05%, the molecular weight is 2 000~ 30 000, and the degree of deacetylation is 91.5% Chito-oligosaccharides inactivates two oral pathogens, Actinobacillus actinobacillus and Streptococcus mutans.
  • Antitumor effect. Chito-oligosaccharides can improve the body's immune activity and anti-cancer ability, and has a significant inhibitory effect on liver cancer cells.
  • Disease prevention and disease resistance of plants. Chito-oligosaccharides also acts as a plant regulator to enhance the plant's defenses against pests and diseases. Oligosaccharides have the functions of regulating plant growth, development, reproduction, disease prevention and resistance, etc., can stimulate the immune system response of plants, activate defense responses, produce active substances with disease resistance, and inhibit the formation of diseases.
3. What are the benefits of Chito-oligosaccharides in dietary food supplements?

Chito-oligosaccharides are fungal-derived alternatives to traditional chitosan that offer a variety of benefits and functions when used as dietary supplements. Here's a detailed overview:

Benefits of Chito-oligosaccharides in dietary supplements:
  • Fat binding and weight management: It can be combined with dietary fats in the digestive system, which may reduce their absorption and aid in weight management.
  • Lowers cholesterol: Helps lower cholesterol by binding to cholesterol in the gut, reducing its absorption into the bloodstream.
  • Gut Health Promotion: As dietary fiber, it contributes to gut health. It may also have prebiotic properties that support beneficial gut microbiota.
  • Blood sugar regulation: It may help stabilize blood sugar levels, which can be beneficial for people with diabetes or insulin resistance.
  • Detoxification: Able to bind to toxins and heavy metals, promoting their excretion from the body.
  • Immune support: There is evidence that it can boost the immune system, but more research is needed.
  • Bone Health: Aids in the absorption of calcium, potentially improving bone health.
  • Antioxidant Effect: Has antioxidant properties to fight oxidative stress in the body.
4. What is the role of Chito-oligosaccharides in dietary food supplements?

Features of dietary supplements:
  • Active Ingredient: Commonly used as the main active ingredient in weight loss and cholesterol management supplements.
  • Fiber supplements: as a source of dietary fiber. It is also considered a prebiotic fiber. It provides food for the beneficial bacteria in the gut.
  • Toxin binders: Used for their ability to bind and help remove toxins from the body. This feature makes it valuable in a variety of health and environmental applications.
Here's a more detailed explanation:
toxin binding mechanism:
  • Chito-oligosaccharides have a positively charged amino group that can attract and bind negatively charged toxins, heavy metals, and other harmful substances.
  • Its molecular structure allows it to form complexes with these toxins, effectively trapping them.
detox application:
  • removes heavy metals: it binds to heavy metals such as lead, mercury, and cadmium, helping to remove them from the body.
  • Lowers cholesterol: Some studies suggest that it can bind to dietary fats and cholesterol and may aid their excretion. Here's an example of such a study:
  • Mycotoxin binding: It has shown the potential to bind to certain mycotoxins, which are toxic compounds produced by fungi.
advantages:
    > biocompatible: Generally considered safe for human use.
  • Biodegradability: Eco-friendly as it decomposes naturally.
  • Non-toxic: Unlike some other antidotes, it is harmless to the body.
consider:
  • effect may vary depending on the specific application requirements.
  • The degree of deacetylation and molecular weight of chitosan oligosaccharides affect their binding capacity.
5. What is the recommended dosage of Chito-oligosaccharides in a dietary/food supplement formulation?
Recommended Dosage:

The optimal dosage of Chito-oligosaccharides in a dietary supplement varies depending on expected usages and individual health needs.

  • For weight management and lowering cholesterol: The dosage is usually between 500 and 3000 mg per day, usually taken before meals.
  • As a fiber supplement: Dosage can vary widely, but should be balanced with adequate water intake.
  • For other health benefits: The exact dosage may depend on the formulation and concentration of chitosan in the supplement.

In conclusion, Chito-oligosaccharides in dietary supplements have several health benefits, especially when it comes to weight management, cholesterol control, and gut health. Dosages should be tailored to individual needs and health goals, and a professional consultation is recommended for personalized advice.

6. Summary of the application of Chito-oligosaccharides in dietary food supplements

Chito-oligosaccharides have a variety of benefits and functions when included in a diet or food supplement. Chito-oligosaccharides are primarily known for their weight management properties, having the ability to bind dietary fats in the digestive system, which helps reduce their absorption and may aid in weight control. It is also recognized for its role in cholesterol management, as it can bind to cholesterol in the gastrointestinal tract, reducing its absorption and potentially lowering overall cholesterol levels. Another significant benefit is its contribution to gut health; As dietary fiber, it enhances intestinal flora balance and overall digestive health.

In addition to these primary functions, Chito-oligosaccharides have also shown promise for blood sugar regulation, making it beneficial for people with diabetes or at risk of diabetes. Its detoxifying properties, in which it binds to toxins and heavy metals, promote their excretion from the body. It also supports bone health by aiding in the absorption of calcium. The antioxidant properties of Chito-oligosaccharides help reduce oxidative stress in the body.

In addition, emerging studies suggest a potential role in boosting the immune system and explore its anti-aging effects. This range of benefits makes Chito-oligosaccharides a versatile and valuable ingredient in dietary supplements that meet a wide range of health and nutritional needs.

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