Chito-oligosaccharides application

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Application of Chito-oligosaccharides in the health management of weight loss

Change your diet: How Chito-oligosaccharides can promote weight loss and boost metabolism

Chitosan Oligosaccharides Introduction

Chitin, which is widely found in shrimp and crab shells, is a polysaccharide made by the polymerization of N acetyl glucosamine.

Chitin is deacetylated to obtain chitosan.

In the past ten years, the research on chitin and chitosan has been widely carried out at home and abroad, and their functions in anti-tumor and prevention and treatment of pathogenic microorganisms have attracted more and more attention. However, due to its insoluble water, it is very limited in the development of applications. To this end, chitosan is degraded into Chito-oligosaccharides (also known as oligosaccharides, chitosan oligosaccharides, chitosan oligosaccharides) by appropriate methods, that is, oligosaccharides composed of 2~10 aminoglycoses linked by β-1-4 glycosidic bonds.

Through a series of experiments, it has been found that it not only has good water solubility, is easy to be absorbed by the human body, but also has a variety of physiological functions such as antibacterial, anti-tumor, blood lipid regulation, immune regulation and activation of intestinal bifidobacteria, and the application field has been greatly broadened.

Chito-oligosaccharides has a unique application value in fine chemicals, biomedicine, health food, agriculture, forestry and animal husbandry.


Chito-oligosaccharides chemical structure

Chito-oligosaccharides is a multifunctional biopolymer derived from chitin that has been widely used in several industries due to its unique properties. This biodegradable and non-toxic compound offers a range of advantages in various areas:

  • Healthcare & Pharmaceutical: The biocompatibility of Chito-oligosaccharides makes it invaluable in medical applications. It is used in wound healing products, drug delivery systems, and as a biomaterial in tissue engineering. Its ability to promote healing and control drug release makes it a popular choice in the pharmaceutical industry.
  • Environmental protection: In water treatment, Chito-oligosaccharides' ability to bind to heavy metals and other contaminants makes it an effective agent in the purification process. This property allows it to be used in industrial and municipal water treatment facilities.
  • Agriculture: Farmers and agronomists utilize Chito-oligosaccharides as natural biostimulants and inducers. It promotes plant growth and strengthens resistance to pathogens, contributing to more sustainable agricultural practices.
  • Food industry: Chito-oligosaccharides have a variety of usages in food production and preservation. It acts as an antimicrobial food additive and can be used to make edible films or coatings to extend the shelf life of perishable products.
  • Beverage production: In the alcoholic beverage industry, Chito-oligosaccharides are used to clarify wine, beer, and whiskey, helping to improve their transparency and stability.
  • Dietary supplements: This compound is also used in the production of dietary supplements, taking advantage of its potential health benefits.
  • Plastics industry: The biodegradable properties of Chito-oligosaccharides make it an attractive option for developing environmentally friendly plastic alternatives.

  • Biological activity. Chito-oligosaccharides has a water solubility of more than 99% and a human absorption rate of 99.88%, which has superior biological activity than chitosan. It can improve the flora distribution of intestinal microbes, stimulate the growth of beneficial bacteria, and its pharmacological activity is 14 times that of chitosan of the same weight. Experiments have shown that Chito-oligosaccharides can proliferate Bifidobacterium by 120 times when applied to dairy products.
  • Antibacterial and antibacterial effect. Chito-oligosaccharides has a pronounced antibacterial and antibacterial effect. Its antibacterial effect is also gradually enhanced with the decrease of the molecular weight of Chito-oligosaccharides, with a molecular weight of 1 814, the degree of deacetylation of 84% Chito-oligosaccharides treated non-woven fabrics, it was found that the concentration of 0.01% against Proteus vulgaris reached 90%, while for Staphylococcus aureus and Escherichia coli, 0.05%, the molecular weight is 2 000~ 30 000, and the degree of deacetylation is 91.5% Chito-oligosaccharides inactivates two oral pathogens, Actinobacillus actinobacillus and Streptococcus mutans.
  • Antitumor effect. Chito-oligosaccharides can improve the body's immune activity and anti-cancer ability, and has a significant inhibitory effect on liver cancer cells.
  • Disease prevention and disease resistance of plants. Chito-oligosaccharides also acts as a plant regulator to enhance the plant's defenses against pests and diseases. Oligosaccharides have the functions of regulating plant growth, development, reproduction, disease prevention and resistance, etc., can stimulate the immune system response of plants, activate defense responses, produce active substances with disease resistance, and inhibit the formation of diseases.
3. What are the benefits and functions of Chito-oligosaccharides in weight loss?

Chito-oligosaccharides are derived from marine crab shells and have a variety of benefits and features that make them a potentially beneficial weight loss aid:

Benefits of Chito-oligosaccharides for weight loss

weight loss support: By preventing the absorption of a portion of the fat ingested, chitosan can help reduce total calorie intake and support weight loss efforts.

cholesterol management: Reduced fat absorption leads to lower cholesterol levels, which is beneficial for cardiovascular health and can indirectly support weight management.

appetite suppression: Although more indirect and affected by individual differences, the presence of chitosan in the digestive system can increase satiety (satiety) and may reduce total calorie intake.

Improves digestive health: As a form of dietary fiber, chitosan can improve digestive health, which is essential for efficient metabolism and weight management.

Functions of Chito-oligosaccharides in weight loss

fat binding: Chito-oligosaccharides binds to dietary lipids in the digestive tract and forms complexes with fats that are too large to be absorbed by the body. This results in a direct reduction in the amount of fat absorbed.

> blood glucose regulation: Chitosan interferes with the absorption of sugar in the gut and helps maintain more stable blood sugar levels, thus preventing high insulin spikes that promote fat storage.

toxin binding: Chitosan binds toxins and heavy metals in the digestive system, helping them to excrete, thereby reducing the body's toxic load.

these features and benefits show how Chito-oligosaccharides can be an effective adjunct to weight management programs, especially when combined with lifestyle changes such as diet and exercise.

4. What is the mechanism of action of Chito-oligosaccharides for weight loss?

Chito-oligosaccharides aid in weight loss through a variety of mechanisms, mainly by interacting with dietary fats and influencing metabolic processes. Here are the features of Chito-oligosaccharides:

fat binding: The main mechanism by which Chito-oligosaccharides aid in weight loss is binding to fat in the stomach. Chito-oligosaccharides are positively charged polymers that can effectively bind to fats (lipids) due to their negative charge at the stomach pH level. This combination produces a large complex of fats and Chito-oligosaccharides that the body cannot absorb. As a result, these complexes are excreted rather than digested, resulting in a decrease in the total caloric intake of fat.

Reduces fat absorption: By binding with dietary fats, Chito-oligosaccharides reduces the amount of fat absorbed in the intestines. Less fat absorption leads to a calorie deficit, which is essential for weight loss.

Appetite suppression: There is some evidence that Chito-oligosaccharides may help reduce appetite. This effect may be due to the increased viscosity of gastric contents after Chito-oligosaccharides bind to fat, which may slow digestion and prolong satiety. This delay in gastric emptying can lead to a decrease in total food intake.

Potential effects on cholesterol: Chito-oligosaccharides also bind to bile acids or cholesterol, which may help lower cholesterol levels in the blood. Lowering cholesterol helps improve overall health and supports metabolic processes that are conducive to weight loss.

Improves gastrointestinal health: Chito-oligosaccharides can help improve gastrointestinal function. A healthy digestive system is essential for an efficient metabolism and can help with weight management by improving nutrient absorption and maintaining regular bowel movements.

Blood sugar regulation: Some research suggests that Chito-oligosaccharides may help stabilize blood sugar levels by reducing the rate of absorption of sugar in the gut. Stable blood sugar levels help prevent insulin spikes, which can lead to fat storage, which supports weight loss efforts.

These different mechanisms make Chito-oligosaccharides a versatile agent in weight loss supplements, capable of influencing dietary fat intake and digestion, as well as influencing overall metabolic health.

5. Chito-oligosaccharides for weight loss

Chito-oligosaccharides provide a multifaceted approach to weight loss. Its main function is fat binding, which interacts with dietary fats in the stomach to form large complexes that cannot be absorbed by the human body, effectively reducing the total calorie intake of fat. In order to achieve this at an optimal level of 6 times the adsorption capacity, Chito-oligosaccharides must be highly deacetylated, at least 98%, and should have an ultra-low molecular weight of 3000 daltons. This mechanism not only helps in direct weight loss, but also helps in controlling cholesterol levels in the blood, contributing to overall cardiovascular health.

Additionally, Chito-oligosaccharides may enhance satiety and slow digestion, which can reduce total calorie consumption by suppressing appetite. Chito-oligosaccharides can improve gastrointestinal health, which can promote regularity and improve nutrient absorption. It may also help stabilize blood sugar levels, which can help control insulin response and prevent sudden spikes in hunger. The multiple functions of Chito-oligosaccharides, including its ability to bind toxins and possibly lower cholesterol, make it a versatile and beneficial supplement for those looking to manage their weight effectively. Its natural origin and absence of the significant side effects typically associated with synthetic drugs further enhance its appeal as a weight management aid.

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